Mechanisms of Chaperones as Active Assistant/Protector for Proteins: Insights from NMR Studies
- 影响因子：
0.0
- DOI码：
10.1002/cjoc.201900441
- 发表刊物：
Chinese Journal of Chemistry
- 关键字：
Chaperone Proteins Protein–protein interactions Dynamics NMR
- 摘要：
Molecular chaperones are diverse families of proteins that play key roles in protein homeostasis. They assist the folding of client proteins or prevent them from irreversible aggregation under stress conditions. Our understanding of the chaperone functional mechanisms, especially regarding chaperoneヽlient interactions, has greatly expanded in recent years, thanks to the significant contribution from various NMR studies. In this review, we summarize some of the current knowledge of molecular chaperones, with emphasis on common features of chaperoneヽlient interactions and examples on a number of specific systems in which solution NMR methods were used to provide essential insights into their functional mechanisms. This article is protected by copyright. All rights reserved.
- 论文编号：
67
- 卷号：
2020
- 期号：
4
- 是否译文：
否
- 第一作者：
Yunfei Hu
- 通讯作者：
Changwen Jin,Maili Liu
- 全部作者：
Conggang Li,Lichun He
