First structure of the polymyxin resistance proteins
- 影响因子：
0.0
- 发表刊物：
Biochem. Biophys. Res. Commun.
- 摘要：
PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.
- 论文类型：
期刊论文
- 论文编号：
17
- 卷号：
361
- 期号：
4
- 页面范围：
1033-1037
- 是否译文：
否
- 发表时间：
2007-10-05
- 收录刊物：
SCI
- 发布期刊链接：
- 第一作者：
Fu Wenyu
- 通讯作者：
Jin Changwen
- 全部作者：
Yang Fan,Kang Xue,Zhang Xinxin,Li You,Xia Bin
