Chitin-induced dimerization activates a plant immune receptor
- 影响因子：
0.0
- 发表刊物：
Science
- 摘要：
Pattern recognition receptors confer plant resistance to pathogen infection by recognizing the conserved pathogen-associated molecular patterns. The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain (AtCERK1-ECD) to activate immune responses. The crystal structure that we solved of an AtCERK1-ECD complexed with a chitin pentamer reveals that their interaction is primarily mediated by a LysM and three chitin residues. By acting as a bivalent ligand, a chitin octamer induces AtCERK1-ECD dimerization that is inhibited by shorter chitin oligomers. A mutation attenuating chitin-induced AtCERK1-ECD dimerization or formation of nonproductive AtCERK1 dimer by overexpression of AtCERK1-ECD compromises AtCERK1-mediated signaling in plant cells. Together, our data support the notion that chitin-induced AtCERK1 dimerization is critical for its activation.
- 论文类型：
期刊论文
- 论文编号：
39
- 卷号：
336
- 期号：
6085
- 页面范围：
1160-1164
- 是否译文：
否
- 发表时间：
2012-06-01
- 收录刊物：
SCI
- 发布期刊链接：
- 第一作者：
Liu Tingting
- 通讯作者：
Chaijijie
- 全部作者：
Zhou Jianmin,Chang Junbiao,Jin Changwen,Wang Jiawei,Fan Fangfang,She Ji,Han Zhifu,Hu Yunfei,Song Chuanjun,Liu Zixu
