Structural and functional characterization of tumor suppressors TIG3 and H-REV107
- 影响因子：
0.0
- 发表刊物：
FEBS Lett.
- 关键字：
H-REV107; NMR; Solution structure; TIG3; Tumor suppressor
- 摘要：
H-REV107-like family proteins TIG3 and H-REV107 are class II tumor suppressors. Here we report that the C-terminal domains (CTDs) of TIG3 and H-REV107 can induce HeLa cell death independently. The N-terminal domain (NTD) of TIG3 enhances the cell death inducing ability of CTD, while NTD of H-REV107 plays an inhibitory role. The solution structure of TIG3 NTD is very similar to that of H-REV107 in overall fold. However, the CTD binding regions on NTD are different between TIG3 and H-REV107, which may explain their functional difference. As a result, the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
- 论文类型：
期刊论文
- 论文编号：
51
- 卷号：
589
- 期号：
11
- 页面范围：
1179-86
- 是否译文：
否
- 发表时间：
2015-05-08
- 收录刊物：
SCI
- 发布期刊链接：
- 第一作者：
Wei Hejia
- 通讯作者：
Xia Bin
- 全部作者：
Wang Lei,Ren Xiaobai,Yu Wenyu,Lin Jian,Jin Changwen
